The Book on Overtraining Syndrome

About the Author

June 27, 2021

Flávio A. Cadegiani, MD, MSc, PhD, obtained his medical degree at University of Brasilia. He then made his medical residency in Internal Medicine, immediately followed by a fellowship in Endocrinology and Metabolism. After the fellowship, which is also termed as a specialization medical residency in some countries, he obtained the Board Certification in Endocrinology and Metabolism, and started two concurrent careers, in the university as a MSc and then PhD student, while he began his clinical practice in his own clinic.

During his researches on fatigue-related conditions, which resulted in the publication of the systematic review “Adrenal Fatigue Does Not Exist: A Systematic Review”, published at the BMC Endocrine Disorders, and which has become a world reference to debunk the existence of this fake disease, he realized that those states that were markedly affected by fatigue had methodological issues in the assessment of hormones and metabolic parameters. Among these states, he was called special attention for overtraining syndrome, for which endocrinology aspects were claimed to be central for the occurrence and as a major manifestation in this disease.

He then performed a systematic review on hormonal aspects on overtraining syndrome, from which he not only concluded that this syndrome lacked massive gaps in the pathophysiological understanding and biomarkers, but also that the research on the endocrinology of physical activity and sport required substantial improvements in the methodological design and assessment methods.

By addressing this methodological issues, and aiming to answer the major questions on overtraining syndrome, as well as on healthy athletes, he conducted the Endocrine and Metabolic Responses on Overtraining Syndrome (EROS) study, which evaluated more than 110 parameters within more than 50 participants, including two control groups, that revealed multiple novel biomarkers and mechanisms not only in overtraining, but also in healthy athletes, and its longitudinal follow-up was still ongoing by the time that the present topic was written. The study has become the largest on its field, with multiple arms and which has been unfolded in more than 10 published papers.

The author currently has the largest number of published researches in the field of Overtraining Syndrome and Sports Endocrinology, has been invited to become of the editorial board of a large number of high-impact PubMed indexed journals, and to review approximately 90% of the manuscripts on the field of Sports Endocrinology submitted to important journals.

Finally, as the first board certified endocrinologist to obtain a PhD degree in the Endocrinology of Physical Activity and Sport in a PhD program of Clinical Endocrinology, he has become an expert in both Endocrinology and Sports Medicine fields, providing a unique endocrinological perspective to Overtraining Syndrome. With the studies and now with the book, Flavio Cadegiani helped to unveil multiple characteristics of this syndrome and to understand the exact pathological mechanisms that affected athletes undergo, as shown in the book.

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